Endocrine Abstracts

A major difficulty of obesity treatments is that patients stop losing weight after a period of responsiveness and often experience a rebound. This could be caused by an impairment in energy balance circuits that becomes irreversible as obesity progresses. To test this hypothesis, we generated a reversible knockout-mouse model of early onset obesity. These mice are unable to express the proopiomelanocortin gene (Pomc) in hypothalamic neurons (CNS-Pomc−/...